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<strong>Fast, scalable alignment and analysis at a price any lab can afford.</strong><br><strong>Highlights<br><br><br>• Accurate<br>Anchored Assembly accurately detects SNPs, indels, and structural variants ranging from 10bp to 100kbp.
<br>• Low false positive rate<br>We optimize Anchored Assembly to ensure a very low false positive rate. <br>• High throughput<br>Reliably detect your variants at the rate that you produce data. <strong>How does Anchored Assembly work?<br/strong>
<br><strong>Available via Cloud or Cluster<br/strong><br><brstrong>Features:</strong>
<br>Variant Detection is currently in beta. If you’d like to be part of our beta program, For more information please contact us at info@spiralgenetics.com<br><br>Pricing starting at $12/GB (volume pricing)
Text replace - "MapReduce" to "Statistical calculation"
{{Bioinformatics application
|sw summary=Spiral Genetics provides a novel aligner/variant caller, Anchored Assembly, which can detect large structural variations using short read NGS data with unmatched precision. See the white paper: http://www.spiralgenetics.com/science/resource-library/|bio domain=Alignment, DNA-Seq, Exome and Whole whole genome variant detection, De novo Assembly, Genomic Assembly, Mappingassembly, Quality Controlcontrol, Read alignmentMapping, Reference Sequence assembly, Resequencing, SNP discoverydetection, Sequence analysis, Whole Genome Resequencinggenome resequencing,Statistical calculation|bio method=AlignmentSequence alignment, De novo AssemblyFile reformatting, Data compression, Genome AlignmentRead mapping, MapReduce
|bio tech=Illumina
|created by=Spiral Genetics
|input format=Fastq, Fastq.gz
|output format=VCF 4.1
|sw feature=Accurate, Fast, Cloud Computing, MappingRead mapping, SNP calling, command line, large SV detection
|language=C++,
|licence=Commercial,
|os=Linux, Mac OS X, Windows
}}
<brstrong>• Highlights</strong>; Accurate : Anchored Assembly accurately detects SNPs, indels, and structural variants ranging from 10bp to 100kbp.; Use existing HiSeq data<br>: Anchored Assembly uses data from HiSeq and MiSeq without special library prep. You can detect structural variants using your existing data.; Low false positive rate : We optimize Anchored Assembly to ensure a very low false positive rate.; High throughput : Reliably detect your variants at the rate that you produce data.
Spiral’s Anchored Assembly uses direct, de novo read overlap assembly to accurately detect SNPs, indels, and structural variants.
We map variant sequences to specific genome locations by “anchoring”, or matching the ends of the assembled variant, to unique sequences present in the reference genome. Assembly begins from these reference-anchored reads and traverses variant regions by constructing a read overlap graph.
* Read Alignment (BWA, Bowtie and T-Map)
* SNPs and Indels (SOAP and Maq)
* Cloud and Cluster Versions
* Ion Torrent Plugin to stream data directly to Spiral Cloud
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