ASC
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Application data |
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| Biological application domain(s) | RNA-Seq quantification |
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| Principal bioinformatics method(s) | Statistics and probability |
| Maintained? | Maybe |
Summary: Empirical Bayes method to detect differential expression.
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Description
ASC borrows information across sequences to establish prior distribution of sample variation, so that biological variation can be accounted for even when replicates are not available. Compared current approaches that simply tests for equality of proportions in two samples, ASC is less biased towards highly expressed sequences and can identify more genes with a greater log fold change at lower overall abundance.
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