Breakway
Revision as of 20:44, 28 April 2010 by Alperyilmaz (talk | contribs)
Application data |
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Created by | Clark, MJ |
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Biological application domain(s) | Whole Genome Resequencing, Genomics, Structural variants, InDel discovery |
Principal bioinformatics method(s) | DNA sequence analysis, genetic variation annotation |
Technology | ABI SOLiD, Solexa, Cross-platform: supports color space and varied read lengths (from Helicos to 454), 454, Sanger |
Created at | UCLA, Stanley F. Nelson Lab, Department of Human Genetics
Sourceforge |
Maintained? | Yes |
Input format(s) | BAM |
Output format(s) | TXT |
Software features | Fast, specific, UNIX pipes |
Programming language(s) | Perl |
Licence | GPL |
Operating system(s) | UNIX/Linux, MacOS X, Windows (probably) |
Summary: Breakway is a suite of programs that take aligned genomic data and report structural variation breakpoints. Features include:
- Takes in BAM formatted input, the current standard for genomic alignments.
- Compatible with standard output from major alignment algorithms such as BFAST, BWA, MAQ, et cetera.
- Capable of analyzing data from any major platform--Solexa, SOLiD, 454, et cetera.
- Empirically identifies structural variation breakpoints.
- Highly specific analysis generates very few false positives.
- Includes a suite of downstream tools for annotating identified breakpoints and reducing false positives.
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