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Short description:
Please summarise the application in a few sentences. Avoid links here. Web server for microRNA profiling and discovery based on high-throughput sequencing
Software version:
Biological application domain(s) (Phylogenetics, Genomics, ...):
Transcriptomics, Regulatory RNA
Principal bioinformatics method(s) (Assembly, Mapping, ...):
Technology (Sanger, Illumina, 454, SOLiD, Ion Torrent, ...):
Illumina, 454
Interface (Command line, Web UI, Desktop GUI, SOAP WS, HTTP WS, API, QL):
Resource type (Command-line tool, Web application, Desktop application, Script, Suite, Workbench, Database portal, Workflow, Plug-in, Library, Web API, Web service, SPARQL endpoint):
Institute of Genomic Medicine, Wenzhou Medical College, Wenzhou 325035, China
A comprehensive web server mirTools was developed to allow researchers to comprehensive characterizes the small RNA transcriptome. With the aid of mirTools, it can: 1) Align the large-scale short reads to the reference genome and exhibit the length distribution; 2) Classify of the large-scale short reads into known categories, such as known miRNAs, non-coding RNA, genomic repeats or coding sequences; 3) Provide detailed annotation information of known miRNAs, such as miRNA/miRNA*, absolute/relative reads count and the most abundant tag; 4) Discovery of the novel miRNAs that have not been characterized before from the large-scale short reads; 5) Identify of the differentially expressed miRNAs between samples according to different count strategies, such as total read tag counts and the most abundant tag of specific miRNA.
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