Difference between revisions of "ChIPmeta"
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{{Bioinformatics application | {{Bioinformatics application | ||
|sw summary=Combining data from ChIP-seq and ChIP-chip. | |sw summary=Combining data from ChIP-seq and ChIP-chip. | ||
| − | |bio domain=Transcription Factor Binding Site identification, ChIP-Seq, ChIP-Chip, | + | |bio domain=Transcription Factor Binding Site identification, ChIP-Seq, ChIP-Chip, |
| − | |bio method= | + | |bio method=Hidden Markov Model |
}} | }} | ||
In HHMM, inference results from individual HMMs in ChIP-seq and ChIP-chip experiments are summarized by a higher level HMM. Simulation studies show the advantage of HHMM when data from both technologies co-exist. Analysis of two well-studied transcription factors, NRSF and CTCF, also suggests that HHMM yields improved TFBS identification in comparison to analyses using individual data sources or a simple merger of the two. | In HHMM, inference results from individual HMMs in ChIP-seq and ChIP-chip experiments are summarized by a higher level HMM. Simulation studies show the advantage of HHMM when data from both technologies co-exist. Analysis of two well-studied transcription factors, NRSF and CTCF, also suggests that HHMM yields improved TFBS identification in comparison to analyses using individual data sources or a simple merger of the two. | ||
Revision as of 21:47, 28 December 2009
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Application data |
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| Biological application domain(s) | Transcription Factor Binding Site identification, ChIP-Seq, ChIP-Chip |
|---|---|
| Principal bioinformatics method(s) | Hidden Markov Model |
| Maintained? | Maybe |
Summary: Combining data from ChIP-seq and ChIP-chip.
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In HHMM, inference results from individual HMMs in ChIP-seq and ChIP-chip experiments are summarized by a higher level HMM. Simulation studies show the advantage of HHMM when data from both technologies co-exist. Analysis of two well-studied transcription factors, NRSF and CTCF, also suggests that HHMM yields improved TFBS identification in comparison to analyses using individual data sources or a simple merger of the two.
