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FreClu

Revision as of 18:55, 2 December 2015 by Dan (talk | contribs) (Text replace - "RNA-Seq Alignment" to "RNA-Seq alignment")
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Application data

Biological application domain(s) RNA-Seq alignment
Principal bioinformatics method(s) Read mapping
Maintained? Maybe

Summary: a frequency-based, de novo short-read clustering method that organizes erroneous short sequences originating in a single abundant sequence into a tree structure; in this structure, each “child” sequence is considered to be stochastically derived from its more abundant “parent” sequence with one mutation through sequencing errors. The root node is the most frequently observed sequence that represents all erroneous reads in the entire tree, allowing the alignment of the reliable representative read to the genome without the risk of mapping erroneous reads to false-positive positions.

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Links

References

  1. . 2009. Genome Research


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