21787385
This reference describes ZINBA.
| PMID | PMID 21787385 |
|---|---|
| Title | ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions |
| Year | 2011 |
| Journal | Genome Biology |
| Author | Rashid NU, Giresi PG, Ibrahim JG, Sun W, Lieb JD. |
| Volume | |
| Start page |
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Full text description
ZINBA (Zero-Inflated Negative Binomial Algorithm) identifies genomic regions enriched in a variety of ChIP-seq and related next-generation sequencing experiments (DNA-seq), calling both broad and narrow modes of enrichment across a range of signal-to-noise ratios. ZINBA models and accounts for factors that co-vary with background or experimental signal, such as G/C content, and identifies enrichment in genomes with complex local copy number variations. ZINBA provides a single unified framework for analyzing DNA-seq experiments in challenging genomic contexts.Software website: http://code.google.com/p/zinba/
