SeqEM
Application data |
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Biological application domain(s) | SNP detection |
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Principal bioinformatics method(s) | Expectation Maximisation |
Maintained? | Maybe |
Summary: Genotype-calling algorithm that estimates parameters underlying the posterior probabilities in an adaptive way rather than arbitrarily specifying them a priori. The algorithm applies the well-known EM algorithm to an appropriate likelihood for a sample of unrelated individuals with next-generation sequence data, leveraging information from the sample to estimate genotype probabilities and the nucleotide-read error rate.
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