SeqEM

Application data
Biological application domain(s)	SNP detection
Principal bioinformatics method(s)	Expectation Maximisation
Maintained?	Maybe

Summary: Genotype-calling algorithm that estimates parameters underlying the posterior probabilities in an adaptive way rather than arbitrarily specifying them a priori. The algorithm applies the well-known EM algorithm to an appropriate likelihood for a sample of unrelated individuals with next-generation sequence data, leveraging information from the sample to estimate genotype probabilities and the nucleotide-read error rate.

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Links

• SeqEM Source code [ edit link ]

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References

1. . 2010. Bioinformatics

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