18798982
This reference describes MACS.
| PMID | PMID 18798982 |
|---|---|
| Title | Model-based analysis of ChIP-Seq (MACS). |
| Year | 2008 |
| Journal | Genome Biology |
| Author | Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nussbaum C, Myers RM, Brown M, Li W, Liu XS. |
| Volume | 9 |
| Start page |
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Full text description
We present Model-based Analysis of ChIP-Seq data, MACS, which analyzes data generated by short read sequencers such as Solexa's Genome Analyzer. MACS empirically models the shift size of ChIP-Seq tags, and uses it to improve the spatial resolution of predicted binding sites. MACS also uses a dynamic Poisson distribution to effectively capture local biases in the genome, allowing for more robust predictions. MACS compares favorably to existing ChIP-Seq peak-finding algorithms, and is freely available.
