20932289
This reference describes SRMA.
| PMID | PMID 20932289 |
|---|---|
| Title | Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA. |
| Year | 2010 |
| Journal | Genome Biology |
| Author | Homer N, Nelson SF. |
| Volume | 11 |
| Start page |
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Full text description
A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genome. A novel short-read micro re-aligner, SRMA, that leverages this correlation to better resolve a consensus of the underlying DNA sequence of the targeted genome is described here.
