CNVer

Application data
Biological application domain(s)	Structural variation, Copy number estimation
Created at	University of Toronto
Maintained?	Yes
Input format(s)	FASTA
Programming language(s)	Perl, C++

Summary: CNVer is a method for CNV detection that supplements the depth-of-coverage with paired-end mapping information, where matepairs mapping discordantly to the reference serve to indicate the presence of variation. CNVer combines this information within a unified computational framework called the donor graph, allowing it to better mitigate the sequencing biases that cause uneven local coverage. CNVer can also reconstruct the absolute copy counts of segments of the donor genome, and work with low coverage datasets.

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Links

• CNVer Homepage [ edit link ]

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References

1. . 2010. Genome Research

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