Difference between revisions of "MISO"
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{{Bioinformatics application | {{Bioinformatics application | ||
|sw summary=An alternative to Cufflinks, MISO (Mixture-of-Isoforms) is a probabilistic framework that quantitates the expression level of alternatively spliced genes. | |sw summary=An alternative to Cufflinks, MISO (Mixture-of-Isoforms) is a probabilistic framework that quantitates the expression level of alternatively spliced genes. | ||
| − | |bio domain=RNA-Seq | + | |bio domain=RNA-Seq quantification, RNA-Seq, Alternative splicing, |
|bio tech=Any, | |bio tech=Any, | ||
|maintained=Yes | |maintained=Yes | ||
Latest revision as of 16:54, 2 December 2015
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Application data |
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| Biological application domain(s) | RNA-Seq quantification, RNA-Seq, Alternative splicing |
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| Technology | Any |
| Maintained? | Yes |
| Input format(s) | SAM/BAM |
Summary: An alternative to Cufflinks, MISO (Mixture-of-Isoforms) is a probabilistic framework that quantitates the expression level of alternatively spliced genes.
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Description
MISO (Mixture-of-Isoforms) is a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA-Seq data, and identifies differentially regulated isoforms or exons across samples. By modeling the generative process by which reads are produced from isoforms in RNA-Seq, the MISO model uses Bayesian inference to compute the probability that a read originated from a particular isoform.
Notes:
1) MISO requires all reads of equal length. i.e. Don't supply with quality trimmed reads.
Links
References
To add a reference for MISO, enter the PubMed ID in the field below and click 'Add'.
Search for "MISO" in the SEQanswers forum / BioStar or:
| Web Search | Wiki Sites | Scientific |
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