22388286
This reference describes Bowtie.
PMID | PMID 22388286 |
---|---|
Title | Fast gapped-read alignment with Bowtie 2 |
Year | 2012 |
Journal | Nature Methods |
Author | Benjamin Langmead, Steven L. Salzberg |
Volume | 9 |
Start page | 357 |
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Full text description
As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.