22388286

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This reference describes Bowtie.

PMID PMID 22388286
Title Fast gapped-read alignment with Bowtie 2
Year 2012
Journal Nature Methods
Author Benjamin Langmead, Steven L. Salzberg
Volume 9
Start page 357


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Full text description

As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.