QSRA
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Application data |
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| Created by | Doug Bryant |
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| Biological application domain(s) | Sequence assembly (de novo assembly) |
| Principal bioinformatics method(s) | Sequence assembly |
| Created at | Oregon State University |
| Maintained? | No |
Summary: Quality-value guided Short Read Assembler, created to take advantage of quality-value scores as a further method of dealing with error. Compared to previous published algorithms, our assembler shows significant improvements not only in speed but also in output quality.
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Quality-value guided Short Read Assembler, was created to take advantage of quality-value scores as a further method of dealing with error. Compared to previous published algorithms, this assembler shows significant improvements not only in speed but also in output quality.
QSRA generally produced the highest genomic coverage, while being faster than VCAKE. QSRA was extremely competitive in its longest contig and N50/N80 contig lengths, producing results of similar quality to those of EDENA and VELVET. QSRA provided a step closer to the goal of de novo assembly of complex genomes, improving upon the original VCAKE algorithm by not only drastically reducing runtimes but also increasing the viability of the assembly algorithm through further error handling capabilities.
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