GenomeBrowse

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Application data

Created by Golden Helix Inc.
Biological application domain(s) Sequence analysis, Sequencing, Sequence alignment, Sequence assembly (de novo assembly), Exome analysis, Exome and whole genome variant detection, Genetics, Whole genome resequencing, Next Generation Sequencing, Genomics
Principal bioinformatics method(s) Sequence alignment visualisation, Sequence assembly visualisation, Visualisation
Technology Illumina, ABI SOLiD, Sanger, 454, Ion Torrent
Created at Golden Helix Inc.
Maintained? Yes
Input format(s) BAM
Operating system(s) Windows, Linux, Mac OS X

Summary: A free genome browser for exploring sequencing pile-up and coverage data with numerous annotation tracks hosted on the cloud.

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Golden Helix GenomeBrowse(TM) was created to improve the user-experience of visualizing sequence data by combining an attractive and informative front end with a robust, performance-driven backend. GenomeBrowse makes the process of exploring DNA-seq and RNA-seq pile-up and coverage data intuitive and powerful.

Visualisation:

  • Zooming and navigation controls that are natural as they mimic panning and scrolling actions users are familiar with.
  • Coverage and pile-up views with different modes to highlight mismatches and look for strand bias.
  • Deep, stable stacking algorithms to look at all reads in a pile-up zoom, not just the first 10 or 20.
  • Context-sensitive information by clicking on any feature. See allele frequencies in control databases, functional predictions of a non-synonymous variants, exon positions of genes, or even details of a single sequenced read.
  • The ability to automatically index and compute coverage data on BAM files in the background.

Golden Helix offers a repository of public annotations on the cloud including dbSNP, 1000 Genomes, NHLBI 6500 Exomes, UCSC Known Genes, Ensembl, the OMIM catalog, and more. All public annotation tracks are hosted on the cloud with on-demand streaming so that users don’t have to download them to start viewing data. Annotations are updated automatically with the most up-to-date information. Additional species are also available including bovine, canine, ovine, and more.

All major platforms are supported with native installers that do not rely on virtual machines and emulators that require significant system memory and lack desktop integration. Multi-core enabled performance gives faster rendering and more scalable, detailed visualization.

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References

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