Crossbow

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Application data

Biological application domain(s) SNP detection
Principal bioinformatics method(s) Read mapping
Created at U Maryland
Maintained? Yes

Summary: Crossbow is a cloud-computing software tool that combines the aligner BOWTIE and the SNP caller SOAPsnp.

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See also: BOWTIE and the SNP caller SOAPsnp.


Crossbow is a scalable software pipeline for whole genome resequencing analysis. It combines Bowtie, an ultrafast and memory efficient short read aligner, and SoapSNP, and an accurate genotyper. These tools are combined in an automatic, parallel pipeline that runs in the cloud (Elastic MapReduce in this case) on a local Hadoop cluster, or on a single computer, exploiting multiple computers and CPUs wherever possible. The pipeline can analyze over 35x coverage of a human genome in one day on a 10-node local cluster, or in 3 hours for about $85 using a 40-node, 320-core cluster rented from Amazon Web Services.

Links


References

  1. . 2009. Genome Biology
  2. . 2010. Nature Biotechnology


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